Genetic Mutation
A permanent change in the DNA sequence of an organism's genome.
Also: gene mutation
Definition
A genetic mutation is a permanent alteration in the nucleotide sequence of an organism's DNA. Mutations can be point mutations (single base changes), insertions, deletions, or chromosomal rearrangements. They may occur spontaneously during DNA replication or be induced by mutagens such as UV radiation or chemicals. Mutations can be neutral, harmful, or occasionally beneficial, and they are the ultimate source of genetic variation in populations.
Example
“A single point mutation in the HBB gene changes one amino acid in hemoglobin, causing red blood cells to deform into a sickle shape under low-oxygen conditions, resulting in sickle cell disease.”
Usage Examples
- 1
“The team applied genetic mutation best practices to improve their biology outcomes significantly.”
- 2
“Understanding genetic mutation is essential for anyone building a career in STEM.”
When & How to Use
Use 'Genetic Mutation' when working in Biology contexts where a genetic mutation is a permanent alteration in the nucleotide sequence of an organism's dna.
- ▸Applying genetic mutation principles during a biology project or initiative
- ▸Explaining genetic mutation to a junior team member or stakeholder unfamiliar with STEM
- ▸Evaluating options or proposals using genetic mutation as a decision-making criterion
Etymology & Origin
The term 'Genetic Mutation' derives from Latin roots and entered STEM professional usage as the field formalised in the 20th century.
History & Evolution
The concept of genetic mutation has evolved alongside STEM. Early practitioners relied on informal methods; structured approaches emerged with the professionalisation of biology in the mid-20th century. Today, genetic mutation is a standard part of STEM practice globally.
Synonyms
- gene mutation
- DNA change
- sequence alteration
- genetic variation
Antonyms / Opposites
- wild type
- unmutated gene
Images
CC-licensed · free to useVideo
Related Terms
- DNA
- Evolution
- Natural Selection
- Gene